The Variant Allele Frequency of p53 Arg72Pro (rs1042522) Polymorphism: A Major Breast Cancer Susceptibility Factor in Saudi and Other Ethnic Groups
نویسندگان
چکیده
منابع مشابه
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولFREQUENCY OF C3435 MDR1 AND A6896G CYP3A5 SINGLE NUCLEOTIDE POLYMORPHISM IN AN IRANIAN POPULATION AND COMPARISON WITH OTHER ETHNIC GROUPS
ABSTRACT Background: It is well recognized that different patients respond in different ways to medications. The inter-individual variations are greater than the intera- individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. The recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the ...
متن کاملAssociation of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population.
BACKGROUND Colorectal cancer (CRC) results from the interaction between environmental exposures and genetic predisposition factors. AIMS A case control study was designed and to investigate the genotype frequencies of P53Arg72Pro polymorphism in Malaysian CRC patients and healthy controls and to determine the associated risk of this polymorphism with CRC predisposition. METHODS In this case...
متن کاملPrimary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism
PURPOSE Apoptosis has been implicated as the mechanism for retinal ganglion cell death in primary open-angle glaucoma (POAG), a complex neurodegenerative disease. There have been inconsistent reports regarding increased risk of POAG and a polymorphism (Arg72Pro) within the tumor suppressor gene, p53. The goal of this study was to examine the role of this polymorphism in susceptibility to POAG i...
متن کاملthe polymorphism p53 arg72pro could not confer the susceptibility of gaining gastric cancer in ardabil province, iran
background : gastric cancer as the fourth most frequent malignancy worldwide was known to have the highest rate among cancer-related disorders in ardabil province. the product of tp53 gene regulated the cell cycle process and acts as a tumor suppressor factor. the polymorphism p53 arg72pro (rs1042522) has been reported to be associated with many type of cancers. the purpose of the present stu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
سال: 2019
ISSN: 2090-083X
DOI: 10.21608/eajbsc.2019.26280